neurogenomics

Neuroplasticity serves as the foundation of learning and memory formation, which are indispensable to our lives. Its deficits give rise to an array of disorders, including dementia and post-traumatic stress disorder (PTSD). We will tackle fundamental questions regarding the epigenetic and transcriptional basis of memory-encoding neuronal ensemble (e.g., engram) formation. To this end, we will employ a multidisciplinary approach that encompasses genomics, mouse genetics, circuit analysis, and bioinformatics.

Our laboratory is built upon two main pillars. 

1. We leverage high-end epigenomics and genomics sequencing technologies to uncover the molecular basis of memory-encoding neuronal ensemble formation. We will employ gene KD/OE, as well as optogenetics technologies, to validate the functional relevance of our findings based on genomics profiles. 

2. We develop novel high-throughput sequencing technologies, such as whole genome history tracing, which will overcome the critical limitations of existing snapshot-type technologies. These advanced methodologies will enable us to gain insights into how the heterogeneity of the neuronal ensemble is generated (see Figure). 

Please also see our research vision regarding the ERC-StG grant (MemoPlasticGenomics).